I would argue that we’re all “inferior” in the sense that we’re ill-adapted to essentially any lifestyle other than the one in which we happened to evolve. (Ask an astronaut.) I don’t think any transhumanist thinkers want to create a “perfect” being; the operative goal is to empower the human species on an individual level. In a foreseeable future scenario, instead of being saddled with the genome one blindly inherits, one can choose to become an active participant — and I find that possibility incredibly liberating and exciting. Transhumanism is not eugenics.
An interview with Mac Tonnies, who has the Posthuman Blues, is a good overview of transhumanist thinking.